TY  - JOUR
PY  - 2018//
TI  - Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study
JO  - Molecular psychiatry
A1  - Erlangsen, Annette
A1  - Appadurai, Vivek
A1  - Wang, Yunpeng
A1  - Turecki, Gustavo
A1  - Mors, Ole
A1  - Werge, Thomas
A1  - Mortensen, Preben B.
A1  - Starnawska, Anna
A1  - Børglum, Anders D.
A1  - Schork, Andrew
A1  - Nudel, Ron
A1  - Bækvad-Hansen, Marie
A1  - Bybjerg-Grauholm, Jonas
A1  - Hougaard, David M.
A1  - Thompson, Wesley K.
A1  - Nordentoft, Merete
A1  - Agerbo, Esben
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10<sup>-8</sup>) and rs6880461 (p-value: 9.5 × 10<sup>-8</sup>), and suicide attempt were identified when adjusting for socio-demographics. Adjusting for mental disorders, three significant associations, all on chromosome 20, were identified: rs4809706 (p-value: 2.8 × 10<sup>-8</sup>), rs4810824 (p-value: 3.5 × 10<sup>-8</sup>), and rs6019297 (p-value: 4.7 × 10<sup>8</sup>). Sub-group analysis of cases with affective disorders revealed SNPs associated with suicide attempts when compared to the general population for gene PDE4B. All SNPs explained 4.6% [CI-95: 2.9-6.3%] of the variation in suicide attempt. Controlling for mental disorders reduced the heritability to 1.9% [CI-95: 0.3-3.5%]. Affective and autism spectrum disorders exhibited a SNP heritability of 5.6% [CI-95: 1.9-9.3%] and 9.6% [CI-95: 1.1-18.1%], respectively. Using the largest sample to date, we identified significant SNP associations with suicide attempts and support for a genetic transmission of suicide attempt, which might not solely be explained by mental disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 1359-4184
UR  - http://dx.doi.org/10.1038/s41380-018-0218-y
ID  - ref1
ER  -