TY  - JOUR
PY  - 2018//
TI  - Single-nucleotide polymorphisms in interleukin 6 (IL-6) gene are associated with suicide behavior in an Iranian population
JO  - Journal of molecular neuroscience
A1  - Eftekharian, Mohammad Mahdi
A1  - Noroozi, Rezvan
A1  - Omrani, Mir Davood
A1  - Sharifi, Zohreh
A1  - Komaki, Alireza
A1  - Taheri, Mohammad
A1  - Ghafouri-Fard, Soudeh
SP  - 414
EP  - 419
VL  - 66
IS  - 3
N2  - Previous association studies have demonstrated the association between immune regulatory genes and suicide behavior. Among these genes are those coding for cytokines. In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation. The rs2069845 was not associated with suicide behavior. The rs1800795 C allele was significantly more common among suicide completers compared with suicide attempters (OR (95% CI) = 1.33 (1.04-1.71)), adjusted P = 0.04). Besides, the rs1800795 was associated with the lethality of suicide attempt in recessive model (adjusted P value = 0.01). Consequently, the present study supports the role of IL-6 in suicide behavior and warrants further researches to confirm its effect and explain the underlying mechanism.<p />  <p>Language: en</p>
LA  - en
SN  - 0895-8696
UR  - http://dx.doi.org/10.1007/s12031-018-1190-3
ID  - ref1
ER  -