TY - JOUR PY - 2019// TI - Risk of fall in patients taking proton pump inhibitors: a meta-analysis JO - QJM: Journal of the Association of Physicians of Great Britain and Ireland A1 - Lapumnuaypol, Kamolyut A1 - Thongprayoon, Charat A1 - Wijarnpreecha, Karn A1 - Tiu, Andrew A1 - Cheungpasitporn, Wisit SP - 115 EP - 121 VL - 112 IS - 2 N2 - BACKGROUND: Fall prevention among older adults is a worldwide public health advocacy because of negative consequences of fall. Recent studies have shown that proton pump inhibitors (PPIs) increase the risk of fall. PPIs are among the widely prescribed medications oftentimes without clear indications. Concerns for safety of long-term use of PPIs have been raised by numerous studies.

METHODS: A systematic review was conducted in MEDLINE and EMBASE databases from inception through March 2018 to identify studies that assessed the association between the use of PPIs and the risk of fall. Effect estimates from the individual study were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird.

RESULTS: Eight observational studies with a total of 367,068 patients were enrolled. There was a significant association between the use of PPIs and the risk of fall with the pooled OR of 1.27 (95% CI, 1.07-1.50). Meta-regression showed significant positive correlations between risk of fall in patients using PPIs and year of study (slopes = +0.25, p <0.001). The data on the risk of fall in patients using H2 receptor antagonists (H2RAs) were limited in 3 studies. The pooled OR of fall in patients using H2RAs was 0.95 (95% CI, 0.75-1.20).

CONCLUSIONS: We demonstrate a significant association between the use of PPIs and increased risk of fall. There is a significant positive correlation between the risk of fall in patients using PPIs and year of study. In addition, there is potentially higher risk of fall among PPIs users over time.

Language: en

LA - en SN - 1460-2725 UR - http://dx.doi.org/10.1093/qjmed/hcy245 ID - ref1 ER -