TY  - JOUR
PY  - 2019//
TI  - Self-poisoning with 60 tablets of Apixaban, a pharmacokinetics case report
JO  - British journal of clinical pharmacology
A1  - Franck, Bénédicte
A1  - Dulaurent, Sylvain
A1  - El Balkhi, Souleiman
A1  - Monchaud, Caroline
A1  - Picard, Nicolas
A1  - Couderc, Sylvain
A1  - Marquet, Pierre
A1  - Saint-Marcoux, Franck
A1  - Woillard, Jean-Baptiste
SP  - 270
EP  - 272
VL  - 85
IS  - 1
N2  - A 67-year-old man was admitted to the emergency department about 5 h after deliberate self-poisoning with 300 mg of Apixaban. The clinical examination did not show any organ dysfunctions or haemorrhagic signs, and the patient's life was not in danger. The first analysis, upon admission, showed a concentration of 2655 μg l<sup>-1</sup> of Apixaban. The Cmax was observed 17 h after the intake (3654 μg l<sup>-1</sup> ), about four times the classical Tmax value (median [range]: 4 h [2-4]). The Apixaban was then eliminated following a first order elimination with a calculated half-life of 10.8 h. The anti-Xa activity seems to be linearly related to concentration up to 4000 μg l<sup>-1</sup>. This report suggests that the use of activated charcoal should be effective up to 17 h after a massive intake.<br><br>© 2018 The British Pharmacological Society.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-5251
UR  - http://dx.doi.org/10.1111/bcp.13790
ID  - ref1
ER  -