TY  - JOUR
PY  - 2019//
TI  - Rare copy number variation in an extremely impulsively violent males
JO  - Genes, brain and behavior
A1  - Vevera, Jan
A1  - Zarrei, Mehdi
A1  - Hartmannová, Hana
A1  - Jedličková, Ivana
A1  - Mušálková, Dita
A1  - Přistoupilová, Anna
A1  - Oliveriusová, Petra
A1  - Trešlová, Helena
A1  - Nosková, Lenka
A1  - Hodaňová, Kateřina
A1  - Stránecký, Viktor
A1  - Jiricka, Vaclav
A1  - Preiss, Marek
A1  - Příhodová, Kateřina
A1  - Šaligová, Jana
A1  - Wei, John
A1  - Woodbury-Smith, Marc
A1  - Bleyer, Anthony J.
A1  - Scherer, Stephen W.
A1  - Kmoch, Stanislav
SP  - e12536
EP  - e12536
VL  - 18
IS  - 6
N2  - The genetic correlates of extreme impulsive violence are poorly understood, and there have been no studies that have systematically characterized a large group of affected individuals both clinically and genetically. We performed a genome-wide rare copy number variant (CNV) analysis in 281 males from 4 Czech prisons who met strict clinical criteria for extreme impulsive violence. Inclusion criteria included age > 18 years, an ICD 10 diagnosis of Dissocial Personality Disorder, and the absence of an organic brain disorder. Participants underwent a structured psychiatric assessment to diagnose extreme impulsive violence and then provided a blood sample for genetic analysis. DNA was genotyped and CNVs were identified using Illumina HumanOmni2.5 SNP array platform. Comparing with 15,500 external population controls we identified 828 rare CNVs (frequency ≤ 0.1% among control samples) in 264 participants. The CNVs impacted 754 genes, with 124 genes impacted more than once (2-25-times). Many of these genes are associated with autosomal dominant or X-linked disorders affecting adult behaviour, cognition, learning, intelligence, specifically expressed in the brain, and relevant to synapses, neurodevelopment, neurodegeneration, obesity and neuropsychiatric phenotypes. Specifically we identified 31 CNVs of clinical relevance in 31 individuals, 59 likely clinically relevant CNVs in 49 individuals, and 17 recurrent CNVs in 65 individuals. Thus, 123 of 281 (44%) individuals had one to several rare CNVs that were likely relevant to impulsive violence. Extreme impulsive violence is genetically heterogeneous and genomic analysis is likely required to identify, further research and specifically treat the causes in affected individuals.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1601-1848
UR  - http://dx.doi.org/10.1111/gbb.12536
ID  - ref1
ER  -