TY  - JOUR
PY  - 2019//
TI  - Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women
JO  - Osteoporosis international
A1  - Sim, M.
A1  - Prince, R. L.
A1  - Scott, D.
A1  - Daly, R. M.
A1  - Duque, G.
A1  - Inderjeeth, C. A.
A1  - Zhu, K.
A1  - Woodman, R. J.
A1  - Hodgson, J. M.
A1  - Lewis, J. R.
SP  - 167
EP  - 176
VL  - 30
IS  - 1
N2  - Numerous sarcopenia definitions are not associated with increased falls-related hospitalization risk over 5 years to 9.5 years in older community-dwelling Australian women. Measures of muscle strength and physical function, but not appendicular lean mass (measured by dual-energy X-ray absorptiometry) may help discriminate the risk of falls-related hospitalization. <br><br>INTRODUCTION: The aim of this prospective, population-based cohort study of 903 Caucasian-Australian women (mean age 79.9 ± 2.6 years) was to compare the clinical utility of four sarcopenia definitions for the prediction of falls-related hospitalization over 9.5 years. <br><br>METHODS: The four definitions were the United States Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP), and modified FNIH (AUS-POP<sub>F</sub>) and EWGSOP (AUS-POP<sub>E</sub>) definitions using Australian population-specific cut points (< 2 SD below the mean of young healthy Australian women). Components of sarcopenia including muscle strength, physical function, and appendicular lean mass (ALM) were quantified using hand grip strength, timed-up-and-go (TUG), and dual-energy X-ray absorptiometry (DXA), respectively. Incident 9.5-year falls-related hospitalization were captured by linked data. <br><br>RESULTS: Baseline prevalence of sarcopenia according to FNIH (9.4%), EWGSOP (24.1%), AUS-POP<sub>F</sub> (12.0%), and AUS-POP<sub>E</sub> (10.7%) differed substantially. Sarcopenia did not increase the relative hazard ratio (HR) for falls-related hospitalization before or after adjustment for age (aHR): FNIH aHR 1.00 95%CI (0.69-1.47), EWGSOP aHR 1.20 95%CI (0.93-1.54), AUS-POP<sub>F</sub> aHR 0.96 95%CI (0.68-1.35), and AUS-POP<sub>E</sub> aHR 1.33 95%CI (0.94-1.88). When examining individual components of sarcopenia, only muscle strength and physical function but not ALM (adjusted for height<sup>2</sup> or BMI) were associated with falls-related hospitalization. <br><br>CONCLUSION: Current definitions of sarcopenia were not associated with falls-related hospitalization risk in this cohort of community-dwelling older Australian women. Finally, measures of muscle strength and physical function, but not ALM (measured by DXA) may help discriminate the risk of falls-related hospitalization.<p />  <p>Language: en</p>
LA  - en
SN  - 0937-941X
UR  - http://dx.doi.org/10.1007/s00198-018-4755-7
ID  - ref1
ER  -