TY  - JOUR
PY  - 2019//
TI  - Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide
JO  - World journal of biological psychiatry
A1  - Dean, Brian
A1  - Tsatsanis, Andrew
A1  - Lam, Linh Q.
A1  - Scarr, Elizabeth
A1  - Duce, James A.
SP  - 1
EP  - 8
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders. <br><br>METHODS: Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder (n = 13), bipolar disorder (n = 12) and age/sex matched controls (n = 13). <br><br>RESULTS: We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females. Levels of copper containing ceruloplasmin was lower in BA 6 from suicide completers whilst levels of amyloid precursor protein, TAU and transferrin were higher in BA 10 from those individuals. The level of prion protein was lower in BA 6 from subjects with major depressive disorder. <br><br>CONCLUSIONS: Our data suggests that perturbation in cortical iron transport proteins is not prevalent in mood disorders. By contrast, our data suggests changes in iron transport proteins in BA 6 and BA 10 are present after suicide completion. If these changes were present before death, they could have had a role in the genesis of the contemplation and completion of suicide.<p />  <p>Language: en</p>
LA  - en
SN  - 1562-2975
UR  - http://dx.doi.org/10.1080/15622975.2018.1555377
ID  - ref1
ER  -