TY  - JOUR
PY  - 2018//
TI  - APOE-ε4 genotype is associated with elevated post-concussion symptoms in military veterans with a remote history of mild traumatic brain injury
JO  - Archives of clinical neuropsychology
A1  - Merritt, Victoria C.
A1  - Lapira, Kristina M.
A1  - Clark, Alexandra L.
A1  - Sorg, Scott F.
A1  - Werhane, Madeleine L.
A1  - Jak, Amy J.
A1  - Bondi, Mark William
A1  - Schiehser, Dawn M.
A1  - Delano-Wood, Lisa
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI). <br><br>METHOD: Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4-). The Neurobehavioral Symptom Inventory (NSI) was the primary outcome measure, from which a total score was derived, as well as three symptom clusters (somatic, cognitive, and affective). <br><br>RESULTS: ANCOVAs showed a significant main effect of ε4 genotype on the NSI total score and somatic symptom cluster after adjusting for posttraumatic stress symptoms and mTBI history (p =.019-.028, ηp2 =.064-.073), such that ε4+ Veterans endorsed significantly greater symptoms than ε4- Veterans. <br><br>CONCLUSIONS: Our findings suggest that genetic risk may help to explain the poorer long-term outcomes often observed in this population.<p />  <p>Language: en</p>
LA  - en
SN  - 0887-6177
UR  - http://dx.doi.org/10.1093/arclin/acy082
ID  - ref1
ER  -