TY  - JOUR
PY  - 2019//
TI  - Out of control? Acting out anger is associated with deficient prefrontal emotional action control in male patients with borderline personality disorder
JO  - Neuropharmacology
A1  - Bertsch, Katja
A1  - Krauch, Marlene
A1  - Roelofs, Karin
A1  - Cackowski, Sylvia
A1  - Herpertz, Sabine C.
A1  - Volman, Inge
SP  - 107463
EP  - 107463
VL  - 156
IS  - 
N2  - Difficulty in anger control and anger-related aggressive outbursts against others are frequently reported by patients with borderline personality disorder (BPD). Although male sex is a known predictor for aggression, hardly any study has addressed the neural correlates of deficient anger control in male patients with BPD. Building on previous reports in female BPD, we investigated the involvement of lateral antero- and dorsal prefrontal cortex in the control of fast emotional actions and its relation to self-reported tendencies to act out anger. 15 medication-free male patients with BPD and 25 age- and intelligence-matched healthy men took part in a social Approach-Avoidance task in the MR-scanner. This task allows the measurement of neural correlates underlying the control of fast behavioral tendencies to approach happy and avoid angry faces. Hypothesis-driven region-of-interest and exploratory whole brain analyses were used to test for activations of antero- and dorsolateral prefrontal regions and their relation with the amygdala during emotional action control as well as their association with self-reported anger out in male patients with BPD and healthy volunteers. Male patients with BPD showed reduced anterolateral prefrontal activations during emotional action control compared to healthy volunteers. Furthermore, anger out was negatively related to antero- and dorsolateral prefrontal activations, while it was positively related to amygdala activity in male patients with BPD. The current results suggest the involvement of antero- and dorsolateral prefrontal regions in controlling and overriding fast emotional actions. Furthermore, deficits in lateral prefrontal emotion control seem to be a common neural mechanism underlying anger-related aggression.<br><br>Copyright © 2018. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0028-3908
UR  - http://dx.doi.org/10.1016/j.neuropharm.2018.12.010
ID  - ref1
ER  -