TY  - JOUR
PY  - 2019//
TI  - The population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): a cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development
JO  - Psychiatry and the Clinical Neurosciences
A1  - Okada, Naohiro
A1  - Ando, Shuntaro
A1  - Sanada, Motoyuki
A1  - Hirata-Mogi, Sachiko
A1  - Iijima, Yudai
A1  - Sugiyama, Hiroshi
A1  - Shirakawa, Toru
A1  - Yamagishi, Mika
A1  - Kanehara, Akiko
A1  - Morita, Masaya
A1  - Yagi, Tomoko
A1  - Hayashi, Noriyuki
A1  - Koshiyama, Daisuke
A1  - Morita, Kentaro
A1  - Sawada, Kingo
A1  - Ikegame, Tempei
A1  - Sugimoto, Noriko
A1  - Toriyama, Rie
A1  - Masaoka, Mio
A1  - Fujikawa, Shinya
A1  - Kanata, Sho
A1  - Tada, Mariko
A1  - Kirihara, Kenji
A1  - Yahata, Noriaki
A1  - Araki, Tsuyoshi
A1  - Jinde, Seiichiro
A1  - Kano, Yukiko
A1  - Koike, Shinsuke
A1  - Endo, Kaori
A1  - Yamasaki, Syudo
A1  - Nishida, Atsushi
A1  - Hiraiwa-Hasegawa, Mariko
A1  - Bundo, Miki
A1  - Iwamoto, Kazuya
A1  - Tanaka, Saori C.
A1  - Kasai, Kiyoto
SP  - 231
EP  - 242
VL  - 73
IS  - 5
N2  - AIM: Adolescence is a crucial stage of psychological development and is critically vulnerable to the onset of psychopathology. However, our understanding of how maturation of endocrine, epigenetics, and brain circuit may underlie the psychological development in adolescence has not been integrated. Here, we introduce our research project, the "population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC)," a longitudinal study to explore the neurobiological substrates of development during adolescence. <br><br>METHODS: Participants in the first wave of the pn-TTC (pn-TTC-1) study were recruited from those of the TTC study, a large-scale epidemiological survey in which 3,171 parent-adolescent pairs were recruited from the general population. Psychological, cognitive, sociological, and physical measures were acquired from participants. Moreover, adolescents and their parents underwent magnetic resonance imaging (MRI) scanning (structural MRI, resting-state functional MRI, and magnetic resonance spectroscopy), and adolescents provided saliva samples for hormone analysis and for deoxyribonucleic acid (DNA) analysis including epigenetics. Furthermore, the second wave (pn-TTC-2) was also performed. <br><br>RESULTS: A total of 301 parent-adolescent pairs participated in the pn-TTC-1 study. Moreover, 281 adolescents participated in the pn-TTC-2 study, 238 of which were recruited from the pn-TTC-1 sample. The instruction for data request is available at: http://value.umin.jp/data-resource.html. <br><br>CONCLUSION: The pn-TTC project is a large-scale and population-neuroscience-based survey with a plan of longitudinal biennial follow-up. Through this approach we seek to elucidate adolescent developmental mechanisms according to bio-psycho-social models. Our current biomarker research project, using minimally-biased samples recruited from the general population, has the potential to expand a new research field of "population neuroscience." This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1323-1316
UR  - http://dx.doi.org/10.1111/pcn.12814
ID  - ref1
ER  -