TY  - JOUR
PY  - 2018//
TI  - Deltamethrin toxicity: a review of oxidative stress and metabolism
JO  - Environmental research
A1  - Lu, Qirong
A1  - Sun, Yaqi
A1  - Ares, Irma
A1  - Anadón, Arturo
A1  - Martínez, Marta
A1  - Martínez-Larrañaga, María-Rosa
A1  - Yuan, Zonghui
A1  - Wang, Xu
A1  - Martínez, María-Aránzazu
SP  - 260
EP  - 281
VL  - 170
IS  - 
N2  - Deltamethrin is widely used worldwide due to its valuable insecticidal activity against pests and parasites. Increasing evidence has shown that deltamethrin causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. For the first time, this review systematically summarizes the deltamethrin toxicity mechanism from the perspective of oxidative stress, including deltamethrin-mediated oxidative damage, antioxidant status, oxidative signaling pathways and modulatory effects of antagonists, synergists and placebos on oxidative stress. Further, deltamethrin metabolism, including metabolites, metabolic enzymes and pathways and deltamethrin metabolite toxicity are discussed. This review will shed new light on deltamethrin toxicity mechanisms and provide effective strategies to ensure pest control and prevention of human and animal poisoning.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0013-9351
UR  - http://dx.doi.org/10.1016/j.envres.2018.12.045
ID  - ref1
ER  -