TY  - JOUR
PY  - 2019//
TI  - Frailty as a predictor of falls in HIV-infected and uninfected women
JO  - Antiviral therapy
A1  - Sharma, Anjali
A1  - Hoover, Donald R.
A1  - Shi, Qiuhu
A1  - Gustafson, Deborah R.
A1  - Plankey, Michael W.
A1  - Tien, Phyllis C.
A1  - Weber, Kathleen M.
A1  - Yin, Michael T.
SP  - 51
EP  - 61
VL  - 24
IS  - 1
N2  - BACKGROUND: Frailty and falls occur commonly and prematurely in HIV-infected populations. Whether frailty in middle-age predicts future falls among HIV-infected women is unknown. <br><br>METHODS: We evaluated associations of frailty with single and recurrent falls 10 years later among 729 HIV-infected and 326 uninfected women in the Women's Interagency HIV Study (WIHS) with frailty measured in 2005 and self-reported falls in 2014-2016. Frailty was defined as ≥3 of 5 Fried Frailty Index components: slow gait, reduced grip strength, exhaustion, unintentional weight loss, and low physical activity. Stepwise logistic regression models determined odds of single (vs. 0) or recurrent falls (≥2 vs. 0) during the two-year period; separate models evaluated frailty components. <br><br>RESULTS: HIV-infected women were older (median 42 vs. 39 yr, p<0.0001) and more often frail (14% vs. 9%, p=0.04) than uninfected women. Over two years, 40% of HIV-infected vs. 39% of uninfected women reported a fall [single fall in 15% HIV+ vs. 18% HIV- women; recurrent falls in 25% HIV+ vs. 20% HIV- women (overall p =0.20)]. In multivariate models, frailty independently predicted recurrent falls [adjusted odds ratio (aOR) 1.84, 95% CI: 1.13-2.97, p=0.01], but not single fall. Among frailty components, unintentional weight loss independently predicted single fall (aOR 2.31, 95% CI: 1.28- 4.17, p=0.005); unintentional weight loss (aOR 2.26, 95% CI: 1.32-3.86, p= 0.003) and exhaustion (aOR 1.66, 95% CI: 1.10- 2.50, p=0.02) independently predicted recurrent falls. <br><br>CONCLUSIONS: Early frailty measurement among middle-aged women with or at-risk for HIV may be a useful tool to assess future fall risk.<p />  <p>Language: en</p>
LA  - en
SN  - 1359-6535
UR  - http://dx.doi.org/10.3851/IMP3286
ID  - ref1
ER  -