TY  - JOUR
PY  - 2018//
TI  - Observer-rated retardation but not agitation corresponds to objective motor measures in depression
JO  - Acta neuropsychiatrica
A1  - Diermen, Linda van
A1  - Walther, Sebastian
A1  - Cools, Olivia
A1  - Fransen, Erik
A1  - Birkenhäger, Tom K.
A1  - Sabbe, Bernard G. C.
A1  - Schrijvers, Didier
SP  - 359
EP  - 364
VL  - 30
IS  - 6
N2  - OBJECTIVETo explore the correlations between observer ratings and instrumental parameters across domains of psychomotor functioning in depression.<br><br>METHODIn total, 73 patients with major depressive disorder underwent extensive psychomotor and clinical testing. Psychomotor functioning was assessed with (i) an observer-rated scale (the CORE measure) and also objectively with (ii) 24-h actigraphy, and (iii) a fine motor drawing task.<br><br>RESULTSObserver ratings of retardation correlated with instrumental assessments of fine and gross motor functioning. In contrast, observer ratings of agitation did not correlate with observer ratings of retardation or with the instrumental measures. These associations were partly influenced by age and, to a lesser extent, by depression severity.<br><br>CONCLUSIONPsychomotor disturbance is a complex concept with different manifestations in depressed patients. Although observer ratings of retardation correspond well with instrumental measures of the motor domains, objective measurement of agitation and other aspects of psychomotor disturbance require further research.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-2708
UR  - http://dx.doi.org/10.1017/neu.2018.21
ID  - ref1
ER  -