TY  - JOUR
PY  - 2019//
TI  - An amygdalar neural ensemble that encodes the unpleasantness of pain
JO  - Science
A1  - Corder, Gregory
A1  - Ahanonu, Biafra
A1  - Grewe, Benjamin F.
A1  - Wang, Dong
A1  - Schnitzer, Mark J.
A1  - Scherrer, Grégory
SP  - 276
EP  - 281
VL  - 363
IS  - 6424
N2  - Pain is an unpleasant experience. How the brain's affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimuli, withdrawal reflexes, anxiety, or reward. Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to drive dysfunctional perceptual changes associated with neuropathic pain, including pain aversion to light touch (allodynia). These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception.<br><br>Copyright © 2019, American Association for the Advancement of Science.<p />  <p>Language: en</p>
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/10.1126/science.aap8586
ID  - ref1
ER  -