TY  - JOUR
PY  - 2019//
TI  - Sex-specific association of depressive disorder and transient emotional states with alcohol consumption in male and female alcoholics
JO  - Drug and alcohol dependence
A1  - Karpyak, Victor M.
A1  - Geske, Jennifer R.
A1  - Hall-Flavin, Daniel K.
A1  - Loukianova, Larissa L.
A1  - Schneekloth, Terry D.
A1  - Skime, Michelle K.
A1  - Seppala, Marvin
A1  - Dawson, George
A1  - Frye, Mark A.
A1  - Choi, Doo-Sup
A1  - Biernacka, Joanna M.
SP  - 31
EP  - 39
VL  - 196
IS  - 
N2  - BACKGROUND: We assessed the impact of comorbid depression and anxiety disorders as well as positive and negative emotional states on alcohol consumption in alcohol dependent men and women. <br><br>METHODS: Per day alcohol consumption during 90 days before enrolment was assessed by the Time Line Follow Back (TLFB) in 287 men and 156 women meeting DSM-IV-TR criteria for alcohol dependence. Propensity to drink in negative/positive emotional states was assessed using the Inventory of Drug Taking Situations (IDTS). Psychiatric comorbidities, including major depressive disorder (MDD), substance-induced depression (SID), anxiety disorders (AnxD), or substance-induced anxiety (SIA) were identified by Psychiatric Research Interview of Substance and Mood Disorders (PRISM). <br><br>RESULTS: In the combined group, increased number of drinks per day and number of heavy drinking days correlated with increased IDTS scores (all p < 0.0001), while the lifetime history of MDD was associated with fewer drinking days (p = 0.045) but not average number of drinks per day. Male sex was associated with higher alcohol consumption per day (p < 0.0001), but not with the number of drinking days (p > 0.05). Lifetime MDD history was associated with less drinking days (p = 0.0084) and less heavy drinking days (p = 0.021) in alcohol dependent men, while current MDD was associated with higher alcohol use per day in alcohol dependent women (p = 0.044). <br><br>CONCLUSIONS: Our findings suggest that emotional states and lifetime MDD history have sex-specific impact on alcohol use in alcohol dependent men and women. The mechanisms underlying these findings and their relevance to treatment outcomes need to be examined in future studies.<br><br>Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0376-8716
UR  - http://dx.doi.org/10.1016/j.drugalcdep.2018.12.010
ID  - ref1
ER  -