TY  - JOUR
PY  - 2019//
TI  - Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: the zebrafish model
JO  - Pharmacological research
A1  - de Abreu, Murilo S.
A1  - Giacomini, Ana C. V. V.
A1  - Genario, Rafael
A1  - dos Santos, Bruna E.
A1  - da Rosa, Larissa G.
A1  - Demin, Konstantin A.
A1  - Wappler-Guzzetta, Edina
A1  - Kalueff, Allan V.
SP  - 602
EP  - 608
VL  - 141
IS  - 
N2  - The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic deterinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Here, we discuss mechanisms of zebrafish aggression and their pharmacological, pharmacogenetic and pharmacogenomic models, as well as recent developments and existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of aggression, fostering future discoveries of potential therapeutic agents for aggressive behavior.<br><br>Copyright © 2019. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 1043-6618
UR  - http://dx.doi.org/10.1016/j.phrs.2019.01.044
ID  - ref1
ER  -