TY  - JOUR
PY  - 2019//
TI  - Comparison of all-cause and cause-specific mortality of persons with traumatic spinal cord injuries to the general Swiss population: results from a national cohort study
JO  - Neuroepidemiology
A1  - Chamberlain, Jonviea D.
A1  - Buzzell, Anne
A1  - Gmünder, Hans Peter
A1  - Hug, Kerstin
A1  - Jordan, Xavier
A1  - Moser, André
A1  - Schubert, Martin
A1  - Zwahlen, Marcel
A1  - Brinkhof, Martin W. G.
SP  - 205
EP  - 213
VL  - 52
IS  - 3-4
N2  - BACKGROUND: Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality. <br><br>OBJECTIVES: To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. <br><br>METHODS: All-cause and cause-specific standardized mortality ratios (SMRs) were calculated using data from the Swiss Spinal Cord Injury cohort study. Cause-specific subhazard ratios were estimated within a competing risk framework using flexible parametric survival models. <br><br>RESULTS: Between 1990 and 2011, 2,492 persons sustained a TSCI, of which 379 died. Persons with TSCI had a mortality rate more than 2 times higher than that of the Swiss general population (SMR 2.32; 95% CI 2.10-2.56). Tetraplegic lesions were associated with an increased risk of mortality due to respiratory and cardiovascular diseases, infections, and accidents. Cause-specific SMRs were notably elevated for SCI-related conditions such as urinary tract infections (UTIs) and septicemia. <br><br>CONCLUSIONS: Elevated SMRs due to cardiovascular disease, UTIs and septicemia-related mortality suggest the need for innovation when managing associated secondary health conditions.<br><br>© 2019 S. Karger AG, Basel.<p />  <p>Language: en</p>
LA  - en
SN  - 0251-5350
UR  - http://dx.doi.org/10.1159/000496976
ID  - ref1
ER  -