TY  - JOUR
PY  - 2019//
TI  - Informed consent for functional MRI research on comatose patients following severe brain injury: balancing the social benefits of research against patient autonomy
JO  - Journal of medical ethics
A1  - Bruni, Tommaso
A1  - Graham, Mackenzie
A1  - Norton, Loretta
A1  - Gofton, Teneille
A1  - Owen, Adrian M.
A1  - Weijer, Charles
SP  - 299
EP  - 303
VL  - 45
IS  - 5
N2  - Functional MRI shows promise as a candidate prognostication method in acutely comatose patients following severe brain injury. However, further research is needed before this technique becomes appropriate for clinical practice. Drawing on a clinical case, we investigate the process of obtaining informed consent for this kind of research and identify four ethical issues. After describing each issue, we propose potential solutions which would make a patient's participation in research compatible with her rights and interests. First, we defend the need for traditional proxy consent against two alternative approaches. Second, we examine the impact of the intensive care unit environment on the informed consent process. Third, we discuss the therapeutic misconception and its potential influence on informed consent. Finally, we deal with issues of timing in recruiting participants and related factors which may affect the risks of participation.<br><br>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-6800
UR  - http://dx.doi.org/10.1136/medethics-2018-104867
ID  - ref1
ER  -