TY  - JOUR
PY  - 2019//
TI  - What is the cause of death, when alcohol dependent persons die prematurely?
JO  - Drug and alcohol dependence
A1  - Abdul Ghani, Ali Mohamad
A1  - Faiz, Edris
A1  - Nielsen, Anette
A1  - Bilberg, Randi
SP  - 120
EP  - 126
VL  - 197
IS  - 
N2  - BACKGROUND: Although individuals with alcohol use disorder (AUD) have a significantly shorter lifespan than the general population, there is sparse evidence on cause of death when alcohol dependent people die prematurely. Especially the somatic causes of death are shed less light on. <br><br>AIM: To determine the cause of premature death in individuals with AUD based on recent studies. <br><br>METHODS: This systematic review summarizes evidence from the last 10 years with cohort studies consisting of AUD patients with the subsequent outcome of cause of death and with at least two years of follow-up. <br><br>RESULTS: Nine studies were included of which only two were assessed to be of good quality. Furthermore, two studies were of moderately good and acceptable quality, respectively. This review found increased mortality in AUD individuals with the main causes of death being malignancy, and problems of the cardiovascular- and the digestive system. <br><br>CONCLUSION: Malignancy was the most common cause of death in the included AUD cohorts, but the overall quality of the included studies in this review is low. There is a need for high-quality studies to better understand cause-specific mortality among AUD individuals.<br><br>Copyright © 2019 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0376-8716
UR  - http://dx.doi.org/10.1016/j.drugalcdep.2018.11.032
ID  - ref1
ER  -