TY  - JOUR
PY  - 2019//
TI  - Resilience is associated with larger dentate gyrus, while suicide decedents with major depressive disorder have fewer granule neurons
JO  - Biological psychiatry
A1  - Boldrini, Maura
A1  - Galfalvy, Hanga
A1  - Dwork, Andrew J.
A1  - Rosoklija, Gorazd B.
A1  - Trencevska-Ivanovska, Iskra
A1  - Pavlovski, Goran
A1  - Hen, René
A1  - Arango, Victoria
A1  - Mann, J. John
SP  - 850
EP  - 862
VL  - 85
IS  - 10
N2  - BACKGROUND: Early life adversity (ELA) increases major depressive disorder (MDD) and suicide risk and potentially affects dentate gyrus (DG) plasticity. We reported smaller DG and fewer granular neurons (GNs) in MDD. ELA effects on DG plasticity in suicide decedents with MDD (MDDSui) and resilient subjects (ELA history without MDD or suicide) are unknown. <br><br>METHODS: We quantified neural progenitor cells (NPCs), GNs, glia, and DG volume in whole hippocampus postmortem in four groups of drug-free, neuropathology-free subjects (N = 52 total): psychological autopsy-defined MDDSui and control subjects with and without ELA (before 15 years of age). <br><br>RESULTS: ELA was associated with larger DG (p <.0001) and trending fewer NPCs (p =.0190) only in control subjects in whole DG, showing no effect on NPCs and DG volume in MDDSui. ELA exposure was associated with more GNs (p =.0003) and a trend for more glia (p =.0160) in whole DG in MDDSui and control subjects. MDDSui without ELA had fewer anterior and mid DG GNs (p <.0001), fewer anterior DG NPCs (p <.0001), and smaller whole DG volume (p =.0005) compared with control subjects without ELA. In MDDSui, lower Global Assessment Scale score correlated with fewer GNs and smaller DG. <br><br>CONCLUSIONS: Resilience to ELA involves a larger DG, perhaps related to more neurogenesis depleting NPCs, and because mature GNs and glia numbers do not differ in the resilient group, perhaps there are effects on process extension and synaptic load that can be examined in future studies. In MDDSui without ELA, smaller DG volume, with fewer GNs and NPCs, suggests less neurogenesis and/or more apoptosis and dendrite changes.<br><br>Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2018.12.022
ID  - ref1
ER  -