TY  - JOUR
PY  - 2019//
TI  - Sex differences in pediatric traumatic brain injury
JO  - Experimental neurology
A1  - Arambula, Sheryl E.
A1  - Reinl, Erin
A1  - El Demerdash, Nagat
A1  - McCarthy, Margaret M.
A1  - Robertson, Courtney L.
SP  - 168
EP  - 179
VL  - 317
IS  - 
N2  - The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.<br><br>Copyright © 2019. Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0014-4886
UR  - http://dx.doi.org/10.1016/j.expneurol.2019.02.016
ID  - ref1
ER  -