TY  - JOUR
PY  - 2019//
TI  - Periaqueductal gray sheds light on dark areas of psychopathology
JO  - Trends in neurosciences
A1  - George, David Theodore
A1  - Ameli, Rezvan
A1  - Koob, George F.
SP  - 349
EP  - 360
VL  - 42
IS  - 5
N2  - Neurons in the periaqueductal gray (PAG) integrate negative emotions with the autonomic, neuroendocrine, and immune systems to facilitate responses to threat. Modern functional track tracing in animals and optogenetic and chemogenetic techniques show that the PAG is a rich substrate for the integration of active and passive responses to threat. In humans, the same regions of the PAG that give rise to adaptive anger/fight, fear/panic, depression/shutdown, pain, and predatory behaviors in response to challenging situations or overwhelming threats can become activated pathologically, resulting in symptoms that resemble those of psychiatric disorders. This review coalesces human and animal studies to link PAG neuropathways to specific elements of psychiatric diagnoses. The insights gained from this overview may eventually lead to new therapeutic interventions.<br><br>Copyright © 2019. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0166-2236
UR  - http://dx.doi.org/10.1016/j.tins.2019.03.004
ID  - ref1
ER  -