TY  - JOUR
PY  - 2019//
TI  - A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking
JO  - International journal of legal medicine
A1  - Le Daré, Brendan
A1  - Allard, Sophie
A1  - Bouvet, Renaud
A1  - Baert, Alain
A1  - Allard, Pierre-Marie
A1  - Morel, Isabelle
A1  - Gicquel, Thomas
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Toxicological analyses of post-mortem samples (using a liquid chromatography high-resolution mass spectrometry (LC-HR-MS) method) highlighted high concentrations of acebutolol and its metabolite diacetolol in femoral blood (92.8 mg/L and 21.2 mg/L, respectively) and other matrices (cardiac blood, urine, bile, and gastric contents). A molecular networking approach provided useful information on acebutolol's metabolism and revealed the existence of an unknown phase II metabolite of acebutolol. Molecular networking also facilitated visualization of the complex LC-HR-MS/MS datasets and the sample-to-sample comparisons that confirmed massive acebutolol intoxication by ingestion.<p />  <p>Language: en</p>
LA  - en
SN  - 0937-9827
UR  - http://dx.doi.org/10.1007/s00414-019-02062-9
ID  - ref1
ER  -