TY  - JOUR
PY  - 2019//
TI  - Stress, epigenetics and depression: a systematic review
JO  - Neuroscience and biobehavioral reviews
A1  - Park, Caroline
A1  - Rosenblat, Joshua Daniel
A1  - Brietzke, Elisa
A1  - Pan, Zihang
A1  - Lee, Yena
A1  - Cao, Bing
A1  - Zuckerman, Hannah
A1  - Kalantarova, Anastasia
A1  - McIntyre, Roger S.
SP  - 139
EP  - 152
VL  - 102
IS  - 
N2  - Environmental stressors, such as childhood maltreatment, have been recognized to contribute to the development of depression. Growing evidence suggests that epigenetic changes are a key mechanism by which stressors interact with the genome leading to stable changes in DNA structure, gene expression, and behaviour. The current review aimed to evaluate the relationship between stress-associated epigenetic changes and depression. Human studies were identified via systematic searching of PubMed/Medline from inception to February 2018. Seventeen articles were identified. Stress-associated epigenetic changes in the following genes were correlated with depression: NRC31, SLCA4, BDNF, FKBP5, SKA2, OXTR, LINGO3, POU3F1 and ITGB1. Epigenetic changes in glucocorticoid signaling (e.g., NR3C1, FKBP5), serotonergic signaling (e.g. SLC6A4), and neurotrophin (e.g., BDNF) genes appear to be the most promising therapeutic targets for future research. However, continued research is warranted due to inconsistent findings regarding the directionality of epigenetic modification. Future studies should also aim to control for the use of psychotropic agents due to their widespread use in depressed populations and established effects on DNA methylation.<br><br>Copyright © 2019. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2019.04.010
ID  - ref1
ER  -