TY  - JOUR
PY  - 2019//
TI  - Anterior segment optical coherence tomographic angiography assessment of acute chemical injury
JO  - American journal of ophthalmology
A1  - Fung, Simon S. M.
A1  - Stewart, Rosalind M. K.
A1  - Dhallu, Sandeep K.
A1  - Sim, Dawn A.
A1  - Keane, Pearse A.
A1  - Wilkins, Mark R.
A1  - Tuft, Stephen J.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - PURPOSE: To compare routine clinical examination with optical coherence tomography angiography (OCTA) for the assessment of limbal conjunctival ischemia following a chemical burn. SETTING: Validity analysis METHODS: We assessed ten participants (15 eyes) with an acute chemical injury. Clinical photographs were used to determine the extent of any limbal conjunctival epithelial defect and ischemia. These were compared with the extent of limbal ischemia identified on OCTA images of the ocular surface. Quantitative and longitudinal analysis using the OCTA software were also performed. Correlations with visual outcome were sought using clinical and OCTA-derived variables. <br><br>RESULTS: The extent of clinically determined limbal ischemia was less than that identified with OCTA (2.3±3.6 clock hours v 5.1±4.2 clock hours, p = 0.003), which in turn was less than the size of limbal conjunctival epithelial defect (7.3±5.1 clock hours, p = 0.03). Longitudinal OCTA analysis showed that mean vessel area increased by 0.2 ±0.1% during the study, corresponding to a rate of vascular recovery of 0.9mm<sup>2</sup>/day. Significant correlations were found between visual outcome at 3 months and limbal conjunctival fluorescein staining (r = 0.67, p = 0.006), and limbal conjunctival ischemia on OCTA (r = 0.76, p = 0.001). <br><br>CONCLUSIONS: OCTA can objectively identify and monitor the recovery of limbal ischemia following an acute ocular chemical injury. OCTA confirms that limbal ischemia is usually more extensive than is suggested by clinical examination, and the former is highly correlated with visual outcome. OCTA therefore is a useful tool in the management of ocular chemical injury.<br><br>Copyright © 2019 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-9394
UR  - http://dx.doi.org/10.1016/j.ajo.2019.04.021
ID  - ref1
ER  -