TY  - JOUR
PY  - 2019//
TI  - Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age
JO  - Elife
A1  - Kuhn, Simone
A1  - Mascharek, Anna
A1  - Banaschewski, Tobias
A1  - Bodke, Arun
A1  - Bromberg, Uli
A1  - Büchel, Christian
A1  - Quinlan, Erin Burke
A1  - Desrivieres, Sylvane
A1  - Flor, Herta
A1  - Grigis, Antoine
A1  - Garavan, Hugh
A1  - Gowland, Penny A.
A1  - Heinz, Andreas
A1  - Ittermann, Bernd
A1  - Martinot, Jean-Luc
A1  - Nees, Frauke
A1  - Papadopoulos Orfanos, Dimitri
A1  - Paus, Tomas
A1  - Poustka, Luise
A1  - Millenet, Sabina
A1  - Fröhner, Juliane H.
A1  - Smolka, Michael N.
A1  - Walter, Henrik
A1  - Whelan, Robert
A1  - Schumann, Gunter
A1  - Lindenberger, Ulman
A1  - Gallinat, Jürgen
SP  - e44056
EP  - e44056
VL  - 8
IS  - 
N2  - Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging.<br><br>© 2019, Kühn et al.<p />  <p>Language: en</p>
LA  - en
SN  - 2050-084X
UR  - http://dx.doi.org/10.7554/eLife.44056
ID  - ref1
ER  -