TY  - JOUR
PY  - 2011//
TI  - Height at 2 and 5 years of age in children born very preterm: the EPIPAGE study
JO  - Archives of disease in childhood: fetal and neonatal edition
A1  - Pierrat, V.
A1  - Marchand-Martin, L.
A1  - Guemas, I.
A1  - Matis, J.
A1  - Burguet, A.
A1  - Picaud, J. C.
A1  - Fresson, J.
A1  - Alberge, C.
A1  - Marret, S.
A1  - Roze, J. C.
A1  - Kamiński, M.
A1  - Larroque, B.
A1  - Ancel, P. Y.
SP  - F348
EP  - 54
VL  - 96
IS  - 5
N2  - OBJECTIVES: To evaluate growth for children born very preterm with particular focus on those born small-for-gestational age (SGA) or with ex utero growth restraint (GR), and to identify risk factors for short stature at 5 years of age. STUDY DESIGN: Population-based study of children born at less than 33 completed weeks of gestation (Étude Epidémiologique sur les Petits Ages Gestationnels (EPIPAGE)). Short stature was defined as height <-2SD on WHO growth curves. Ex utero GR was considered to have occurred in children with appropriate size for gestational age at birth and with a height and/or weight below -2SD at 2 years of corrected age. Logistic regression models were used to test associations between risk factors and short stature. <br><br>RESULTS: The authors measured height at 5 years of age for 1,597 of 2,193 children (73%), 5.6% (95% CI 4.6 to 6.9) of whom were diagnosed as having a short stature. Height was measured at 2 and 5 years of age in 1417 children. Among these, 24% of those born SGA and 36% of those with ex utero GR (p=0.002) had a short stature at 5 years. Predictors of short stature were SGA or birth length <-2SD, maternal height ≤ 160 cm, gestational age <29 weeks and systemic corticosteroids. Breastfeeding at discharge decreased the risk of short stature. <br><br>CONCLUSIONS: Short stature at 5 years of age is common in children born preterm. The highest incidence was observed in the group with ex utero GR. Systemic steroids have a long-term impact on growth and should be used with caution. Breastfeeding at discharge appeared to be protective.<p /> <p>Language: en</p>
LA  - en
SN  - 1359-2998
UR  - http://dx.doi.org/10.1136/adc.2010.185470
ID  - ref1
ER  -