TY  - JOUR
PY  - 2019//
TI  - Venoms and isolated toxins from snakes of medical impact in the Northeast Argentina: state of the art. Potential pharmacological applications
JO  - Current topics in medicinal chemistry
A1  - Garcia Denegri, María Emilia
A1  - Bustillo, Soledad
A1  - Gay, Claudia Carolina
A1  - Van De Velde, Andrea
A1  - Gomez, Gabriela
A1  - Echeverría, Silvina
A1  - Gauna Pereira, María Del Carmen
A1  - Maruñak, Silvana
A1  - Nuñez, Sandra
A1  - Bogado, Fabián
A1  - Sanchez, Matías
A1  - Teibler, Gladys Pamela
A1  - Fusco, Luciano
A1  - Leiva, Laura Cristina Ana
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.<br><br>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.<p />  <p>Language: en</p>
LA  - en
SN  - 1568-0266
UR  - http://dx.doi.org/10.2174/1568026619666190725094851
ID  - ref1
ER  -