TY  - JOUR
PY  - 2019//
TI  - Risk factors for suicidality in patients with panic disorder: a systematic review and meta-analysis
JO  - Neuroscience and biobehavioral reviews
A1  - Tietbohl-Santos, Bárbara
A1  - Chiamenti, Paula
A1  - Librenza-Garcia, Diego
A1  - Cassidy, Ryan
A1  - Zimerman, Aline
A1  - Manfro, Gisele Gus
A1  - Kapczinski, Flavio
A1  - Passos, Ives Cavalcante
SP  - 34
EP  - 38
VL  - 105
IS  - 
N2  - BACKGROUND: Subjects with panic disorder are nearly 4 times as likely to attempt suicide as compared to subjects without this condition. <br><br>METHODS: We searched the literature from Jan 1, 1960 to May, 4, 2019. Articles that reported a dichotomous sample of patients with panic disorder with and without suicidal behavior were included. OUTCOMES: Twelve studies with 1958 participants were included. Comorbid depression (k = 3, ES = 4.47 [2.63; 7.60]), depressive symptoms (k = 2, ES = 1.98 [1.26; 3.11]), older age (k = 3, ES = 1.66 [1.32; 2.10]), younger age of panic disorder onset (k = 2, ES = 0.65 [0.45; 0.94]), and history of alcohol dependence (k = 2, ES = 8.70 [1.20; 63.04]) were associated with suicide attempt in panic disorder. Depressive symptoms (k = 2, ES = 2.29 (1.60; 3.37]), anxiety symptoms (k = 2, ES = 1.90 [1.33; 2.69]), longer illness duration (k = 2, ES = 3.31 [1.90; 5.74]), comorbid depressive disorder (k = 4, ES = 3.88 [2.03; 7.41]), agoraphobia (k = 2, ES = 4.60 [1.47; 14.42]) and younger age of onset (k = 2, ES = 0.60 [0.38; 0.96]) were associated with suicidal ideation in panic disorder. <br><br>INTERPRETATION: Our findings provide a framework for the development of suicide prevention strategies in this population.<br><br>Copyright © 2019. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2019.07.022
ID  - ref1
ER  -