TY  - JOUR
PY  - 2019//
TI  - Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
JO  - Annals of clinical and translational neurology
A1  - Antelmi, Elena
A1  - Pizza, Fabio
A1  - Donadio, Vincenzo
A1  - Filardi, Marco
A1  - Sosero, Yuri L.
A1  - Incensi, Alex
A1  - Vandi, Stefano
A1  - Moresco, Monica
A1  - Ferri, Raffaele
A1  - Marelli, Sara
A1  - Ferini-Strambi, Luigi
A1  - Liguori, Rocco
A1  - Plazzi, Giuseppe
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.<br><br>© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.<p />  <p>Language: en</p>
LA  - en
SN  - 2328-9503
UR  - http://dx.doi.org/10.1002/acn3.50833
ID  - ref1
ER  -