TY  - JOUR
PY  - 2019//
TI  - The viewing of a 'bloodcurdling' horror movie increases platelet reactivity: a randomized cross-over study in healthy volunteers
JO  - Thrombosis research
A1  - van Diemen, J. J. K.
A1  - van Dijk, A.
A1  - Racca, C.
A1  - Knol, T.
A1  - Bonten, T. N.
A1  - Numans, M. E.
A1  - Fuijkschot, W. W.
A1  - Smulders, Y. M.
A1  - Thijs, A.
SP  - 27
EP  - 32
VL  - 182
IS  - 
N2  - BACKGROUND: Epidemiological studies have suggested an increased risk of cardiovascular events (CVE) during acute stressful and/or frightful moments. A possible explanation for this could be an effect of acute stress on hemostasis. A recent study demonstrated an increase in factor VIII after watching a horror movie. Primary hemostasis, however, is thought to play a more prominent role in the etiology of CVE. The objective of this study was therefore to assess the influence of viewing a 'bloodcurdling' horror movie on platelet reactivity in healthy volunteers. <br><br>METHODS: We performed a randomized cross-over study in healthy adults. Subjects were allocated to two movies in random sequence: a horror and a control movie. Blood was drawn at baseline and after 24 min of viewing time. The primary endpoint was the change in Platelet Function Analyzer® Closure Time (Δ PFA-CT) after watching the movie. <br><br>RESULTS: In total, 20 participants, aged 18-30 years, completed the study protocol. The delta PFA-CT was statistically significantly shorter with a mean in the delta difference of -9.7 s (SEM 4.0, 95% C.I. -18.0 to -1.3) during the horror movie versus the control movie. The Light Transmission Aggregometry endpoints were in line with the PFA-CT, albeit only the highest level of Arachidonic Acid agonist demonstrated a statistically significant mean difference in the delta of aggregation of 13.15% (SEM 7.0, 95% C.I. 1.6-27.9). <br><br>CONCLUSION: A 'blood curdling' horror movie increases platelet reactivity. These data are supportive of a role of platelet reactivity in acute stress induced cardiovascular event risk.<br><br>Copyright © 2019 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0049-3848
UR  - http://dx.doi.org/10.1016/j.thromres.2019.07.028
ID  - ref1
ER  -