TY  - JOUR
PY  - 2019//
TI  - Association of corticotropin-releasing hormone receptor-1 gene polymorphisms and personality traits with violent aggression in male adolescents
JO  - Journal of molecular neuroscience
A1  - Liu, Li
A1  - Qiao, Yi
A1  - Shao, Yang
A1  - Yu, Shun-Ying
A1  - Zhang, Chen
A1  - Zhang, Ran
A1  - Wang, Dong-Xiang
A1  - Zhao, Min
A1  - Xie, Bin
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - There is evidence that corticotropin-releasing hormone receptor 1 (CRHR1) gene polymorphisms and indifferent impulsive personality traits play an important role in violent aggression in male adolescents. Genotyping for two tag single-nucleotide polymorphisms (SNP) (rs242924, rs17689966) was conducted using TaqMan SNP for 138 violent young male criminals, 98 nonviolent young male criminals, and 153 noncriminal adults. The general situation and personality traits (SSP) questionnaire was given to the young violent and nonviolent male criminal groups. The results showed that the frequency of the G allele in rs242924 of the CRHR1 gene in the violent aggression group was higher than that in the normal adult controls (P < 0.025, OR = 2.29, 95% CI = 1.13-4.62). The difference in genotype distribution was significant among the three groups (P < 0.05), and when the violent group was compared with the two control groups, no significant difference was found (P > 0.025). The impulsiveness, trait irritability, verbal trait aggression, and physical trait aggression scores in the violent group were significantly higher than those in the nonviolent group of adolescents. These findings suggest that the variance in CRHR1 gene polymorphisms and personality traits may play a role in violent aggression in male adolescents, and that the interaction of the CRHR1 gene and the impulsive personality trait may cause an increased susceptibility to violence towards others.<p />  <p>Language: en</p>
LA  - en
SN  - 0895-8696
UR  - http://dx.doi.org/10.1007/s12031-019-01396-8
ID  - ref1
ER  -