TY  - JOUR
PY  - 2019//
TI  - An activatable NIR-II nanoprobe for in vivo early real-time diagnosis of traumatic brain injury
JO  - Angewandte Chemie (International ed. in English)
A1  - Wang, Qiangbin
A1  - Li, Chunyan
A1  - Li, Wanfei
A1  - Li, Zijing
A1  - Zhang, Yejun
A1  - Chen, Guangcun
A1  - Liu, Huanhuan
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis and real-time feedback on the pathological process. Herein, a targeted activatable fluorescent nanoprobe (V&A@Ag 2 S) in the second near-infrared window (NIR-II) is presented for  in vivo  optical imaging of TBI. Initially, the fluorescence of V&A@Ag 2 S displays an "off" state owing to energy transfer from Ag 2 S to the A1094 chromophore. Upon intravenous injection, V&A@Ag 2 S quickly accumulates in the inflamed vascular endothelium of TBI based on VCAM1-mediated endocytosis, after which the nanoprobe achieves rapid recovery of the NIR-II fluorescence of Ag 2 S quantum dots (QDs) due to the bleaching of A1094 by the prodromal biomarker of TBI, peroxynitrite (ONOO -  ). Taking advantage of the deep tissue penetration and high signal-to-noise ratio of NIR-II fluorescence imaging, this nanoprobe offers high specificity, rapid response, and high sensitivity toward ONOO - , providing a convenient approach for  in vivo  early real-time assessment of TBI.<br><br>© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.<p />  <p>Language: en</p>
LA  - en
SN  - 1433-7851
UR  - http://dx.doi.org/10.1002/anie.201911803
ID  - ref1
ER  -