TY  - JOUR
PY  - 2019//
TI  - Neurobiological research with suicidal participants: a framework for investigators
JO  - General hospital psychiatry
A1  - Ballard, Elizabeth D.
A1  - Waldman, Laura
A1  - Yarrington, Julia S.
A1  - Gerlus, Nimesha
A1  - Newman, Laura E.
A1  - Lee, Laura
A1  - Sparks, Mary
A1  - Liberty, Victoria
A1  - Pao, Maryland
A1  - Park, Lawrence
A1  - Zarate, Carlos A.
SP  - 43
EP  - 48
VL  - 62
IS  - 
N2  - OBJECTIVE: Suicide is a public health threat. Nevertheless, the research literature on actively suicidal participants is relatively sparse, in part because they are often excluded from medical, psychiatric, and psychological research for a host of logistical, ethical, and safety concerns. These obstacles to research participation and enrollment may contribute to our lack of understanding regarding the neurobiology of the suicidal crisis as well as to the dearth of evidence concerning both risk prediction and treatment. <br><br>METHOD: In order to directly investigate neurobiological markers of acute suicide risk, the National Institute of Mental Health Intramural Research Program (NIMH-IRP) implemented the Neurobiology of Suicide protocol. In this protocol, actively suicidal individuals consent to research for both neurobiological assessment and potential rapid-acting interventions. <br><br>RESULTS AND CONCLUSIONS: This article reviews lessons learned from implementing this protocol in the hopes of assisting future research on the neurobiology of suicide. Areas of specific discussion include the Failure Modes and Effects Analysis (FMEA), recruitment and informed consent, participant monitoring, and the safety of the physical environment.<br><br>Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0163-8343
UR  - http://dx.doi.org/10.1016/j.genhosppsych.2019.11.007
ID  - ref1
ER  -