TY  - JOUR
PY  - 2019//
TI  - Xiaoyao pills prevent lipopolysaccharide-induced depression by inhibiting inflammation and protecting nerves
JO  - Frontiers in pharmacology
A1  - Shi, Boyu
A1  - Luo, Jie
A1  - Fang, Yang
A1  - Liu, Xiaobo
A1  - Rao, Zhili
A1  - Liu, Rong
A1  - Zeng, Nan
SP  - e1324
EP  - e1324
VL  - 10
IS  - 
N2  - Lipopolysaccharides are pro-inflammation mediators that can induce inflammation in the serum, hippocampus, and cortex of animals. And lipopolysaccharide-induced neuroinflammatory state resulted in significant depression-like behaviors, including reduced locomotor activity in the open field test, reduced saccharin preference, added immobility time in tail suspension test and forced swimming test, decreased comb time in the splash test, and increased latency to food in the novelty suppressed feeding test time, and reduced the levels of neurotrophic factors and synaptic proteins, and decreased Nissl bodies. Treatment with Xiaoyao Pills ameliorated the depression-like behavior, decreased the levels of inflammatory indicators, increased those of neurotrophic factors and synaptic proteins, and restored Nissl bodies. Our study suggests that lipopolysaccharides induce inflammation and nerve injury, thereby leading to depression. Xiaoyao Pills could be considered a potential therapeutic candidate for inflammation-induced depression.<br><br>Copyright © 2019 Shi, Luo, Fang, Liu, Rao, Liu and Zeng.<p />  <p>Language: en</p>
LA  - en
SN  - 1663-9812
UR  - http://dx.doi.org/10.3389/fphar.2019.01324
ID  - ref1
ER  -