TY  - JOUR
PY  - 2019//
TI  - Influence of intranasal oxytocin on fear consolidation in healthy humans
JO  - General psychiatry
A1  - Hoge, Elizabeth
A1  - Bui, Eric
A1  - Rosencrans, Peter
A1  - Orr, Scott
A1  - Ross, Rachel
A1  - Ojserkis, Rebecca
A1  - Simon, Naomi
SP  - e100131
EP  - e100131
VL  - 32
IS  - 6
N2  - BACKGROUND: Although recent data in healthy humans suggestthat treatment with intranasal oxytocin (OT) may facilitate extinction recall,to date, little is known about the effects of OT on memory consolidationprocesses. <br><br>AIM: To examine the effect of intranasal administration of OT compared with placebo on memory consolidation blockade of a de novo fear memory in a classical 2-day fear conditioning procedure. <br><br>RESULTS: There were no significant differences between the OT and the placebo groups on the first two extinction trials (mean (SD)=0.01 (0.39) vs 0.15 (0.31), t=-1.092, p=0.28). Similarly, during early extinction, analysis of variance for repeated measures failed to show significant main effects of extinction trials: trials (<i>F</i>(4, 112)=1.58, p=0.18), drug (<i>F</i>(1, 112)=0.13, p=0.72) or drug × trials interaction (<i>F</i>(4, 112)=0.76, p=0.56). <br><br>CONCLUSION: Our results suggest that OT administered in a double-blind fashion immediately after fear conditioning does not significantly reduce consolidation of fear learning as measured by a differential skin conductance response tested at the beginning of extinction.<br><br>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.<p />  <p>Language: en</p>
LA  - en
SN  - 2517-729X
UR  - http://dx.doi.org/10.1136/gpsych-2019-100131
ID  - ref1
ER  -