TY  - JOUR
PY  - 2020//
TI  - Iron packaging regulations in the United States and pediatric morbidity: a retrospective cohort study
JO  - Clinical pediatrics
A1  - Leonard, James B.
A1  - Hines, Elizabeth Quaal
A1  - Klein-Schwartz, Wendy
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Iron poisoning was a leading cause of pediatric morbidity and mortality. We sought to assess whether the removal of strict iron packaging requirements in 2003 resulted in an increase in iron-related morbidity and mortality in pediatric exposures. We performed a retrospective cohort study utilizing the National Poison Data System from 2000 to 2017. A total of 4110 exposures met inclusion criteria: 847 from before (2000-2003) and 3263 after removal of unit-dose package regulations (2004-2017). The incidence of any marker of severity (7.2% vs 3.8%; odds ratio = 0.51, 95% confidence interval = 0.37-0.69) and frequency of deferoxamine use were both higher in the early time period (2.6% vs 1.0%; odds ratio = 0.38, 95% confidence interval = 0.22-0.66). There was no difference in the frequency of key serious effects (acidosis, elevated transaminases, hypotension). Despite removal of iron packaging regulations in the United States, there continues to be a decrease in the incidence of severe iron exposures in children.<p />  <p>Language: en</p>
LA  - en
SN  - 0009-9228
UR  - http://dx.doi.org/10.1177/0009922819901010
ID  - ref1
ER  -