TY  - JOUR
PY  - 2020//
TI  - Amanita fuliginea poisoning with thrombocytopenia: a case series
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Wang, Qiang
A1  - Sun, Meifeng
A1  - Lv, Hailin
A1  - Lu, Peng
A1  - Ma, Chengjun
A1  - Liu, Yun
A1  - Liu, Shuqin
A1  - Tong, Haiqing
A1  - Hu, Zhao
A1  - Gao, Yanxia
SP  - 43
EP  - 47
VL  - 174
IS  - 
N2  - Amanita fuliginea (A. fuliginea) poisoning is an uncommon and potentially fatal amatoxin exposure. We present 3 cases of severe A. fuliginea poisoning associated with thrombocytopenia in China. Three patients consumed foraged A. fuliginea and developed nausea, vomiting, abdominal pain, and diarrhea. They were transferred from primary clinics to our hospital 19-39 h after mushroom ingestion. They all presented with acute hepatic injury, coagulopathy, thrombocytopenia (6-41 × 10<sup>9</sup>/L), and positive fecal occult blood. Intravenous fluids and antioxidants were administered immediately after admission. Fibrinogen and platelets were given to patients A, B and C. Patient A developed fulminant liver failure and died on day 5 after mushroom exposure. Patients B and C recovered and were discharged on days 11 and 9, respectively. The main targets of A. fuliginea poisoning are the liver and digestive tract. To our knowledge this is the first report of thrombocytopenia associated with A. fuliginea ingestion.<br><br>Copyright © 2019 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/10.1016/j.toxicon.2019.12.156
ID  - ref1
ER  -