TY  - JOUR
PY  - 2020//
TI  - Childhood maltreatment and clinical severity of treatment-resistant depression in a French cohort of outpatients (FACE-DR): One-year follow-up
JO  - Depression and anxiety
A1  - Yrondi, Antoine
A1  - Aouizerate, Bruno
A1  - Bennabi, Djamila
A1  - Richieri, Raphaëlle
A1  - d'Amato, Thierry
A1  - Bellivier, Frank
A1  - Bougerol, Thierry
A1  - Horn, Mathilde
A1  - Camus, Vincent
A1  - Courtet, Philippe
A1  - Doumy, Olivier
A1  - Genty, Jean-Baptiste
A1  - Holtzmann, Jérôme
A1  - Lançon, Christophe
A1  - Leboyer, Marion
A1  - Llorca, Pierre M.
A1  - Maruani, Julia
A1  - Moirand, Remi
A1  - Molière, Fanny
A1  - Samalin, Ludovic
A1  - Schmitt, Laurent
A1  - Stephan, Florian
A1  - Turecki, Gustavo
A1  - Vaiva, Guillame
A1  - Walter, Michel
A1  - Petrucci, Jean
A1  - Haffen, Emmanuel
A1  - El-Hage, Wissam
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Childhood maltreatment is associated with major depressive disorder (MDD). It not only increases the risk of lifetime MDD, but it also aggravates its course. Among depressed patients, 20-30% of them experience treatment-resistance depression (TRD). We aimed to assess the association between childhood maltreatment, severity of depression in a unipolar TRD sample, and patient outcomes after one-year of follow-up. <br><br>METHODS: Patients were recruited for a prospective cohort from the French network of TRD expert centers. Depressive symptom severity was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR). Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire (CTQ). <br><br>RESULTS: In total, 256 patients filled in the CTQ at baseline between 2012 and 2019. At baseline, the MADRS score was associated with CTQ score (β = .185; p = .004). QIDS was also associated with CTQ scores (β = .27; p < .001). Regarding the different subtypes of childhood maltreatment, MADRS was associated with physical (β = .21; p = .005) and sexual abuse (β = .22; p = .002), while QIDS with physical abuse (β = .304; p < .001) and physical neglect (β = .254; p < .001). However, we did not find any significant association focusing on the other types of traumas. During a 1-year follow-up focusing on remission, CTQ scores (baseline) were less important in remittent patients [n = 38; CTQ score = 39.26 (9.68)] than in nonremittent ones [n = 92; CTQ score = 46.02 (17.53)] (p = .027). There was no significant difference among remitters and nonremitters based on trauma subtypes. At baseline, CTQ scores had a significant influence on remission at 1 year (χ<sup>2</sup> (1) = 5.57; p < .05). We lost this influence adding MADRS scores at baseline in the model (p = .063). <br><br>CONCLUSION: We highlighted a significant association between the severity of depressive disorders and childhood maltreatment in the TRD population. Information about a history of childhood maltreatment helps in identifying individuals who could be less likely to go into remission after treatment.<br><br>© 2020 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.22997
ID  - ref1
ER  -