TY  - JOUR
PY  - 2020//
TI  - A neuroeconomic investigation of <i>5-HTT</i>/<i>5-HT1A</i> gene variation, social anxiety, and risk-taking behavior
JO  - Anxiety, stress, and coping
A1  - Stamatis, Caitlin A.
A1  - Engelmann, Jan B.
A1  - Ziegler, Christiane
A1  - Domschke, Katharina
A1  - Hasler, Gregor
A1  - Timpano, Kiara R.
SP  - 1
EP  - 17
VL  - ePub
IS  - ePub
N2  - <b>Background and objectives:</b> Although approaches combining behavioral genetics and neuroeconomics have advanced models of addiction, no study has synthesized these methods to elucidate mechanisms of competing risk-approachand risk-avoidance in social anxiety (SA). Grounded in dual-mode models of serotonergic systems and self-regulation, this study investigated associations between SA, serotonin transporter <i>5-HTT</i> (LPR; rs25531) and receptor <i>5-HT1A</i> genes, and risk-taking on behavioral and self-report measures.<b>Design and methods:</b> Young adults (<i>N </i>= 309) completed a neuroeconomic task measuring gambling attractiveness (<i>δ</i>), reward probability discrimination (<i>γ</i>), and risk attitudes (<i>α</i>). Risk genotypes included <i>5-HTT</i> (LPR; rs25531) low-expression variants (SS/SL<sub>G</sub>/L<sub>G</sub>L<sub>G</sub>), and <i>5-HT1A</i> (rs6295) GG.<b>Results:</b> Path analysis revealed that SA related to increased gambling attractiveness, but only for <i>5-HT1A</i> risk groups. Although the <i>5-HTT</i> (LPR; rs25531) risk genotypes and self-reported SA predicted lower social risk-taking, high-SA individuals who exhibited more accurate reward probability discrimination (<i>γ</i>) reported taking increased social risks.<b>Conclusion:</b> In line with dual-mode models, results suggest that SA predicts behavioral risk-approach at the basic decision-making level, along with self-reported social risk-avoidance, modulated by serotonergic genotypes. High-SA individuals with more accurate assessments of reward probabilities may engage in greater social risk-taking, perhaps reflecting an adaptive tendency to approach feared situations.<p />  <p>Language: en</p>
LA  - en
SN  - 1061-5806
UR  - http://dx.doi.org/10.1080/10615806.2020.1722597
ID  - ref1
ER  -