TY  - JOUR
PY  - 2020//
TI  - Effects of earthquake and related environmental factors on relationship of posttraumatic stress disorder with LDLR rs5925
JO  - Science of the total environment
A1  - Chen, Xu
A1  - Lin, Jia
A1  - Kong, Ling Nan
A1  - Shen, Yi Lin
A1  - Chen, Yong Li
A1  - Guo, Qi Wei
A1  - Zhang, Ji Cheng
A1  - Yang, Mei
A1  - Fang, Ding Zhi
SP  - e136811
EP  - e136811
VL  - 714
IS  - 
N2  - To test the relationship not yet explored before among earthquake and related environmental factors, low-density lipoprotein receptor (LDLR) and posttraumatic stress disorder (PTSD), the genetic variation of LDLR rs5925 was selected and PTSD was examined by PTSD Checklist-Civilian Version (PCLC) in adolescents with different genotypes of LDLR rs5925 longitudinally at 6, 12 and 18 months after the 2008 Wenchuan earthquake. The C allele carriers were observed to have higher PTSD prevalence than the TT homozygotes in the male subjects, and higher PTSD prevalence and PCL-C scores in the female subjects only at 6 months. When compared to that at 12 months, decreased PTSD prevalence was observed at 18 months only in the female C allele carriers, but not in the female TT homozygotes or the male subjects. The potential risk factors of PTSD and predictors of PCL-C scores were different during the follow-up. LDLR rs5925 was one of the predictors for PCL-C scores at 6 and 12 months, and one of the potential factors for PTSD prevalence at 6 months. These results suggest that interactions may occur between earthquakes and other related environmental factors, which could affect the relationship of LDLR rs5925 with PTSD and be considered for individualized treatment.<br><br>Copyright © 2020 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0048-9697
UR  - http://dx.doi.org/10.1016/j.scitotenv.2020.136811
ID  - ref1
ER  -