TY  - JOUR
PY  - 2020//
TI  - Kawasaki disease following severe sunburn injury
JO  - Frontiers in pediatrics
A1  - Okada, Seigo
A1  - Hashimoto, Shintaro
A1  - Miyake, Akiko
A1  - Okada, Yusuke
A1  - Hirano, Reiji
A1  - Fukunaga, Shinnosuke
A1  - Ishikawa, Yuichi
SP  - e6
EP  - e6
VL  - 8
IS  - 
N2  - <b>Background:</b> Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis. Various etiological pathogens have been proposed as the trigger of KD and a scaled injury preceding symptom onset has been reported as one of them. Here, we report a 17-month-old Japanese female who was hospitalized due to high fever lasting for 4 days with infection ruled out as a cause. On admission, she displayed severe sunburn all over her body following a prolonged period of outdoor play 5 days ago. On the 5 day of illness, she developed complete KD. Serum levels of high mobility group box 1, a representative for damage-associated molecular patterns (DAMPs), were elevated during acute phase and continued to decrease during subacute phase. This unique course suggested the inflammatory process of KD involving innate immunity via DAMPs.<br><br>Copyright © 2020 Okada, Hashimoto, Miyake, Okada, Hirano, Fukunaga and Ishikawa.<p />  <p>Language: en</p>
LA  - en
SN  - 2296-2360
UR  - http://dx.doi.org/10.3389/fped.2020.00006
ID  - ref1
ER  -