TY  - JOUR
PY  - 2020//
TI  - Characteristics and circumstances of death related to gamma hydroxybutyrate (GHB)
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Darke, Shane
A1  - Peacock, Amy
A1  - Duflou, Johan
A1  - Farrell, Michael
A1  - Lappin, Julia
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - <b>Introduction:</b> Gamma hydroxybutyrate (GHB) has gained substantial popularity as an illicit recreational drug. The current study aimed to: (1) determine the characteristics and circumstances of death of all recorded cases of GHB-related death in Australia, 2001-2019; (2) determine the toxicology of cases; and (3) determine major organ pathology.<b>Methods:</b> Retrospective study of all Australian cases in which GHB was a mechanism contributory to death retrieved from the National Coronial Information System (<i>n</i> = 74). Information was collected on cause of death, demographics, circumstances of death, toxicology and major organ pathology.<b>Results:</b> The mean age was 31.5 years and 70.3% were male. The predominant circumstance of death was accidental drug toxicity (79.7%), including five cases attributed to a combination of toxicity and natural disease. Other deaths were due to trauma (12.2%) and suicide (8.2%). The fatal incident overwhelmingly occurred in a home environment (82.4%). In all cases, GHB was consumed orally. The median GHB blood concentration was 210 mg/L (range 13-1350 mg/L), and was significantly higher in toxicity cases than others (258 vs. 98 mg/L, <i>p</i> < .01). Other substances were present in 92.2%, most commonly psychostimulants (64.1%), hypnosedatives (28.2%) and alcohol (20.3%). Resuscitation was attempted in 20.3% of cases. Acute pneumonia (36.7%) and aspiration of vomitus (30.6%) were common.<b>Conclusions:</b> The typical case was a young male, who swallowed GHB and used it with other substances, most commonly at home. While acute drug toxicity was the most common cause of death, there was a substantial minority due to trauma or suicide.<p />  <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650.2020.1726378
ID  - ref1
ER  -