TY  - JOUR
PY  - 2020//
TI  - Simultaneous detection of salivary Δ<sup>9</sup>-tetrahydrocannabinol and alcohol using a wearable electrochemical ring sensor
JO  - Talanta
A1  - Mishra, Rupesh K.
A1  - Sempionatto, Juliane R.
A1  - Li, Zhanhong
A1  - Brown, Christopher
A1  - Galdino, Nathalia M.
A1  - Shah, Rushabh
A1  - Liu, Shuyang
A1  - Hubble, Lee J.
A1  - Bagot, Kara
A1  - Tapert, Susan
A1  - Wang, Joseph
SP  - e120757
EP  - e120757
VL  - 211
IS  - 
N2  - Driving under the influence of cannabis and alcohol represents a major safety concern due to the synergistic or additive effect of these substances of abuse. Hence, rapid road-site testing of these substances is highly desired to reduce risks of fatal accidents. Here we describe a wearable electrochemical sensing device for the simultaneous direct, decentralized, detection of salivary THC and alcohol. The new ring-based sensing platform contains a voltammetric THC sensor and an amperometric alcohol biosensor on the ring cap, along with the wireless electronics embedded within the ring case. Rapid replacement of the disposable sensing-electrode ring cap following each saliva assay is accomplished by aligning spring-loaded pins, mounted on the electronic board (PCB), with the current collectors of the sensing electrodes. The printed dual-analyte sensor ring cover is based on a MWCNT/carbon electrode for the THC detection along with a Prussian-blue transducer, coated with alcohol oxidase/chitosan reagent layer, for the biosensing of alcohol. THC and alcohol can thus be detected simultaneously in the same diluted saliva sample within 3 min, with no cross talk and no interferences from the saliva matrix. The new wearable ring sensor platform should enable law enforcement personnel to screen drivers in a single traffic stop and offers considerable promise for addressing growing concerns of drug-impaired driving.      Keyword: Cannabis impaired driving  <br><br>Copyright © 2020 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0039-9140
UR  - http://dx.doi.org/10.1016/j.talanta.2020.120757
ID  - ref1
ER  -