TY  - JOUR
PY  - 2020//
TI  - Amygdala response to emotional faces in adolescents with persistent post-concussion symptoms
JO  - Neuroimage: clinical
A1  - Bohorquez-Montoya, Luisa
A1  - España, Lezlie Y.
A1  - Nader, Amy M.
A1  - Furger, Robyn E.
A1  - Mayer, Andrew R.
A1  - Meier, Timothy B.
SP  - e102217
EP  - e102217
VL  - 26
IS  - 
N2  - Approximately 30% of adolescents with concussion develop persistent post-concussion symptoms (PPCS) that include emotional symptoms. Elevated amygdalae reactivity to emotional faces has been reported in a variety of psychopathologies characterized by emotional symptoms overlapping with those in PPCS. We tested the hypothesis that amygdalae reactivity to emotional faces in adolescents with PPCS+ is elevated compared to concussed adolescents without PPCS and healthy controls. Concussed adolescents (ages 14-18) with (PPCS+; n = 23) and without PPCS (PPCS-; n = 13) participated in visits at least 4 weeks post-injury. Adolescents without prior concussion served as controls (HC; n = 15). All participants completed a detailed clinical battery and a common emotional face processing task that involved matching of emotional faces or shapes. Compared to HC and PPCS-, adolescents with PPCS+ had elevated depression symptoms, anhedonia, general psychological symptoms, and anxiety symptoms. Contrary to our hypothesis, PPCS+ had lower amygdalae activity to the emotional faces versus shapes condition relative to HC and a trend for lower activity relative to PPCS-. There was a non-significant inverse association between anhedonia amygdalae activity in adolescents with PPCS. <br><br>RESULTS suggest that adolescents with PPCS have altered amygdalae activity during the processing of emotional face stimuli.<br><br>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 2213-1582
UR  - http://dx.doi.org/10.1016/j.nicl.2020.102217
ID  - ref1
ER  -