TY  - JOUR
PY  - 2020//
TI  - Trends in microbial profile of burn patients following an event of dust explosion at a tertiary medical center
JO  - BMC infectious diseases
A1  - Chen, Yin-Yin
A1  - Wu, Ping-Feng
A1  - Chen, Chii-Shya
A1  - Chen, Ian-Horng
A1  - Huang, Wan-Tsuei
A1  - Wang, Fu-Der
SP  - e193
EP  - e193
VL  - 20
IS  - 1
N2  - BACKGROUND: Microbial infection is the main cause of increased morbidity and mortality in burn patients, especially infections caused by multiple drug-resistant organisms (MDRO). The purpose of this study was to explore major microbial trends in burn patients. <br><br>METHODS: This retrospective study was conducted at burn wards and intensive care units, where burn patients were admitted following an event of dust explosion. Data were collected for a number of variables including severity of burns, demographic and clinical characteristics, laboratory data, and therapeutic devices. <br><br>RESULTS: A total of 1132 specimens were collected from 37 hospitalized burn patients with mean TBSA of 46.1%.The most commonly isolated species were Staphylococcus spp. (22.4%). The highest rate of antibiotic resistance was observed in carbapenem-resistant A. baumannii (14.6%), followed by methicillin-resistant S. aureus (11.3%). For each additional 10% TBSA, the isolation of MDRO increased 2.58-17.57 times (p < 0.05); for each additional 10% of the third-degree burn severity, the risk of MDRO significantly decreased by 47% (95% CI, 0.38-0.73, p < 0.001) by Cox model. <br><br>CONCLUSIONS: The proportion of overall microbial isolates increased with the increase in TBSA and duration of time after burns. The extent of TBSA was the most important factor affecting MDRO.<p />  <p>Language: en</p>
LA  - en
SN  - 1471-2334
UR  - http://dx.doi.org/10.1186/s12879-020-4920-4
ID  - ref1
ER  -