TY  - JOUR
PY  - 2020//
TI  - Brain metabolic alterations herald falls in patients with Parkinson's disease
JO  - Annals of clinical and translational neurology
A1  - Isaias, Ioannis U.
A1  - Brumberg, Joachim
A1  - Pozzi, Nicoló G.
A1  - Palmisano, Chiara
A1  - Canessa, Andrea
A1  - Marotta, Giorgio
A1  - Volkmann, Jens
A1  - Pezzoli, Gianni
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Pathophysiological understanding of gait and balance disorders in Parkinson's disease is insufficient and late recognition of fall risk limits efficacious follow-up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6-8 months before their first fall episode. Falls in Parkinson's disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.<br><br>© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.<p />  <p>Language: en</p>
LA  - en
SN  - 2328-9503
UR  - http://dx.doi.org/10.1002/acn3.51013
ID  - ref1
ER  -