TY  - JOUR
PY  - 2020//
TI  - Evolutionary puzzle of Toxoplasma gondii with suicidal ideation and suicide attempts: an updated systematic review and meta-analysis
JO  - Transboundary and emerging diseases
A1  - Amouei, Afsaneh
A1  - Moosazadeh, Mahmood
A1  - Nayeri Chegeni, Tooran
A1  - Sarvi, Shahabeddin
A1  - Mizani, Azadeh
A1  - Pourasghar, Mehdi
A1  - Hosseini Teshnizi, Saeed
A1  - Hosseininejad, Zahra
A1  - Dodangeh, Samira
A1  - Pagheh, Abdolsattar
A1  - Pourmand, Amir Hossein
A1  - Daryani, Ahmad
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - The World Health Organization has reported an annual global suicide rate of 14.5 per 100, 000 people. On the other hand, it is estimated that approximately one-third of the global population are infected with Toxoplasma gondii (T. gondii) parasite. It is widely assumed that microbial pathogens, such as T. gondii, are probably associated with affective and behavioral modulation. The present article aimed to assess the proposed role of toxoplasmosis in raising the risk of suicidal ideation (SI) and suicide attempts (SA) using the available epidemiological data. Seven major electronic databases and the internet search engine Google were searched for all the studies published between the 1<sup>st</sup> of January 1950 and 31<sup>st</sup> of October, 2019. The heterogeneity and the risk of bias within and across studies were assessed. Following data extraction, pooled odds ratios (ORs) with 95% confidence interval (CI) across studies were calculated using the random-effects models. A total number of 9696 articles were screened and 27 studies were regarded as eligible in our systematic review (SI with 5 papers and 22 papers on SA). A significant association were detected between antibodies against T. gondii with TA (ORs = 1.57; 95% confidence interval (CI) 1.23-2.00, P = 0.000). Exploration of the association between T. gondii and SA yielded a positive effect of seropositivity for IgG antibodies but not IgM. Despite the limited number of studies, a statistical association was detected between suicidal behaviors and infection with latent T. gondii.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1865-1674
UR  - http://dx.doi.org/10.1111/tbed.13550
ID  - ref1
ER  -