TY  - JOUR
PY  - 2020//
TI  - Continuous opioid monitoring along with nerve agents on a wearable microneedle sensor array
JO  - Journal of the American Chemical Society
A1  - Mishra, Rupesh K.
A1  - Goud, K. Yugender
A1  - Li, Zhanhong
A1  - Moonla, Chochanon
A1  - Mohamed, Mona A.
A1  - Tehrani, Farshad
A1  - Teymourian, Hazhir
A1  - Wang, Joseph
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - There are urgent needs for sensing devices capable of distinguishing between episodes of opioid overdose and nerve agent poisoning. This work presents a wearable microneedle sensor array for minimally invasive continuous electrochemical detection of opioid (OPi) and organophosphate (OP) nerve agents on a single patch platform. The new multimodal microneedle sensor array relies on unmodified and organophosphorus hydrolase (OPH) enzyme-modified carbon paste (CP) microneedle electrodes for square wave voltammetric (SWV) detection of the fentanyl and nerve agent targets, respectively. Such real-time simultaneous sensing provides distinct unique information, along with attractive analytical performance, including high sensitivity, selectivity, and stability, for real-time on-body OPi-OP analysis. The patch represents the first sensing device capable of continuously monitoring fentanyl down to the nanomolar level through a nanomaterial-based multilayered surface architecture. Applicability of the sensor array toward opioids screening is demonstrated for morphine and norfentanyl. Successful OPi-OP detection conducted in a skin-mimicking phantom gel demonstrates the suitability of the device for rapid on-body sensing. Such progress toward continuous minimally invasive transdermal analysis of drugs of abuse and nerve agents holds promise for rapid countermeasures for protecting soldiers, civilians, and healthcare personnel.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-7863
UR  - http://dx.doi.org/10.1021/jacs.0c01883
ID  - ref1
ER  -