TY  - JOUR
PY  - 2020//
TI  - Sensation-seeking is related to functional connectivities of the medial orbitofrontal cortex with the anterior cingulate cortex
JO  - NeuroImage
A1  - Wan, Zhuo
A1  - Rolls, Edmund T.
A1  - Cheng, Wei
A1  - Feng, Jianfeng
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Sensation-seeking is a multifaceted personality trait with components that include experience-seeking, thrill and adventure seeking, disinhibition, and susceptibility to boredom, and is an aspect of impulsiveness. We analysed brain regions involved in sensation-seeking in a large-scale study with 414 participants and showed that the sensation-seeking score could be optimally predicted from the functional connectivity with typically (in different participants) 18 links between brain areas (measured in the resting state with fMRI) with correlation r=0.34 (p=7.3×10<sup>-13</sup>) between the predicted and actual sensation-seeking score across all participants. Interestingly, 8 of the 11 links that were common for all participants were between the medial orbitofrontal cortex and the anterior cingulate cortex and yielded a prediction accuracy r=0.30 (p=4.8×10<sup>-10</sup>). We propose that this important aspect of personality, sensation-seeking, reflects a strong effect of reward (in which the medial orbitofrontal cortex is implicated) on promoting actions to obtain rewards (in which the anterior cingulate cortex is implicated). Risk-taking was found to have a moderate correlation with sensation-seeking (r=0.49, p=3.9×10<sup>-26</sup>), and three of these functional connectivities were significantly correlated (p<0.05) with the overall risk-taking score. This discovery helps to show how the medial orbitofrontal and anterior cingulate cortices influence behaviour and personality, and indicate that sensation-seeking can involve in part the medial orbitofrontal cortex reward system, which can thereby become associated with risk-taking and a type of impulsiveness.<br><br>Copyright © 2020. Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8119
UR  - http://dx.doi.org/10.1016/j.neuroimage.2020.116845
ID  - ref1
ER  -